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A Substrate-induced Biotin Binding Pocket in the Carboxyltransferase Domain of Pyruvate Carboxylase

Biotin-dependent enzymes catalyze carboxyl transfer reactions by efficiently coordinating multiple reactions between spatially distinct active sites. Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxal...

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Bibliografiske detaljer
Main Authors: Lietzan, Adam D., St. Maurice, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707692/
https://ncbi.nlm.nih.gov/pubmed/23698000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477828
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