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The Long-Range P3 Helix of the Tetrahymena Ribozyme Is Disrupted During Folding Between the Native and Misfolded Conformations

RNAs are prone to misfolding, but how misfolded structures are formed and resolved remains incompletely understood. The Tetrahymena group I intron ribozyme folds in vitro to a long-lived misfolded conformation (M) that includes extensive native structure but is proposed to differ in topology from th...

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מידע ביבליוגרפי
Main Authors: Mitchell, David, Jarmoskaite, Inga, Seval, Nikhil, Seifert, Soenke, Russell, Rick
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706569/
https://ncbi.nlm.nih.gov/pubmed/23702292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.008
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