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Folding pathways of the Tetrahymena ribozyme

Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with k(obs) ≈ 0.6 min(–1), while the remainder forms a long-lived misfolded conformation (M) thought...

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Détails bibliographiques
Auteurs principaux: Mitchell, David, Russell, Rick
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177526/
https://ncbi.nlm.nih.gov/pubmed/24747051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.04.011
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