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Folding pathways of the Tetrahymena ribozyme
Like many structured RNAs, the Tetrahymena group I intron ribozyme folds through multiple pathways and intermediates. Under standard conditions in vitro, a small fraction reaches the native state (N) with k(obs) ≈ 0.6 min(–1), while the remainder forms a long-lived misfolded conformation (M) thought...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4177526/ https://ncbi.nlm.nih.gov/pubmed/24747051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.04.011 |
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