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Enhanced Specificity Against Misfolding in a Thermostable Mutant of the Tetrahymena Ribozyme

Structured RNAs encode native conformations that are more stable than the vast ensembles of alternative conformations, but how this specificity is evolved is incompletely understood. Here we show that a variant of the Tetrahymena group I intron ribozyme that was generated previously by in vitro sele...

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Detalles Bibliográficos
Main Authors: Wan, Yaqi, Russell, Rick
Formato: Artigo
Idioma:Inglês
Publicado: 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227551/
https://ncbi.nlm.nih.gov/pubmed/21174447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101467q
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