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Enhanced Specificity Against Misfolding in a Thermostable Mutant of the Tetrahymena Ribozyme
Structured RNAs encode native conformations that are more stable than the vast ensembles of alternative conformations, but how this specificity is evolved is incompletely understood. Here we show that a variant of the Tetrahymena group I intron ribozyme that was generated previously by in vitro sele...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227551/ https://ncbi.nlm.nih.gov/pubmed/21174447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101467q |
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