Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft

The particle fabrication technique PRINT® was used to fabricate monodisperse size and shape specific poly(lactide-co-glycolide) particles loaded with the chemotherapeutic Docetaxel. The pharmacokinetics of two cylindrical shaped particles with diameter=80nm; height=320nm (PRINT-Doc-80×320) and d=200...

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Detalhes bibliográficos
Main Authors: Chu, Kevin S., Hasan, Warefta, Rawal, Sumit, Walsh, Mark D., Enlow, Elizabeth M., Luft, J. Christopher, Bridges, Arlene S., Kuijer, Jennifer L., Napier, Mary E., Zamboni, William C., DeSimone, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706026/
https://ncbi.nlm.nih.gov/pubmed/23219874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2012.11.008
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