Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft

The particle fabrication technique PRINT® was used to fabricate monodisperse size and shape specific poly(lactide-co-glycolide) particles loaded with the chemotherapeutic Docetaxel. The pharmacokinetics of two cylindrical shaped particles with diameter=80nm; height=320nm (PRINT-Doc-80×320) and d=200...

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Autors principals: Chu, Kevin S., Hasan, Warefta, Rawal, Sumit, Walsh, Mark D., Enlow, Elizabeth M., Luft, J. Christopher, Bridges, Arlene S., Kuijer, Jennifer L., Napier, Mary E., Zamboni, William C., DeSimone, Joseph M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706026/
https://ncbi.nlm.nih.gov/pubmed/23219874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2012.11.008
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