Discovery and Preliminary Structure–Activity Relationship of Arylpiperazines as Novel, Brain-Penetrant Antiprion Compounds

[Image: see text] Creutzfeldt-Jakob disease and kuru in humans, BSE in cattle, and scrapie in sheep are fatal neurodegenerative disorders. Such illnesses are caused by the conversion and accumulation of a misfolded pathogenic isoform (termed PrP(Sc)) of a normally benign, host cellular protein, deno...

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Main Authors: Li, Zhe, Gever, Joel R., Rao, Satish, Widjaja, Kartika, Prusiner, Stanley B., Silber, B. Michael
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704178/
https://ncbi.nlm.nih.gov/pubmed/23847718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300472n
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