Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification

Many fungi restructured their proteomes through incorporation of serine (Ser) at thousands of protein sites coded by the leucine (Leu) CUG codon. How these fungi survived this potentially lethal genetic code alteration and its relevance for their biology are not understood. Interestingly, the human...

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Detalhes bibliográficos
Main Authors: Bezerra, Ana R., Simões, João, Lee, Wanseon, Rung, Johan, Weil, Tobias, Gut, Ivo G., Gut, Marta, Bayés, Mónica, Rizzetto, Lisa, Cavalieri, Duccio, Giovannini, Gloria, Bozza, Silvia, Romani, Luigina, Kapushesky, Misha, Moura, Gabriela R., Santos, Manuel A. S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704024/
https://ncbi.nlm.nih.gov/pubmed/23776239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302094110
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