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Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
The cysteine protease legumain plays important functions in immunity and cancer at different cellular locations, some of which appeared conflicting with its proteolytic activity and stability. Here, we report crystal structures of legumain in the zymogenic and fully activated form in complex with di...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3703970/ https://ncbi.nlm.nih.gov/pubmed/23776206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300686110 |
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