Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis: Focus on Matrix Metalloproteinases, Their Endogenous Tissue Inhibitors, and the Proteasome

The leading complication of total joint replacement is periprosthetic osteolysis, which often results in aseptic loosening of the implant, leading to revision surgery. Extracellular matrix degradation and connective tissue remodeling around implants have been considered as major biological events in...

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Bibliographic Details
Main Authors: Syggelos, Spyros A., Aletras, Alexios J., Smirlaki, Ioanna, Skandalis, Spyros S.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703793/
https://ncbi.nlm.nih.gov/pubmed/23862137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/230805
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