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Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis: Focus on Matrix Metalloproteinases, Their Endogenous Tissue Inhibitors, and the Proteasome

The leading complication of total joint replacement is periprosthetic osteolysis, which often results in aseptic loosening of the implant, leading to revision surgery. Extracellular matrix degradation and connective tissue remodeling around implants have been considered as major biological events in...

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Detalhes bibliográficos
Main Authors: Syggelos, Spyros A., Aletras, Alexios J., Smirlaki, Ioanna, Skandalis, Spyros S.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703793/
https://ncbi.nlm.nih.gov/pubmed/23862137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/230805
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