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Osteoclast derived matrix metalloproteinase-7 but not matrix metalloproteinase-9 contributes to tumor induced osteolysis

The matrix metalloproteinases, MMP-2, -3, -7, -9 and -13 are highly expressed in the tumor-bone microenvironment and of these, MMP-7 and MMP-9 were found to be localized to bone resorbing osteoclasts in human breast to bone metastases. In a bid to define the roles of host derived MMP-7 and MMP-9 in...

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Detalhes bibliográficos
Main Authors: Thiolloy, Sophie, Halpern, Jennifer, Holt, Ginger E., Schwartz, Herbert S., Mundy, Gregory R., Matrisian, Lynn M., Lynch, Conor C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745595/
https://ncbi.nlm.nih.gov/pubmed/19679556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3949
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