Simvastatin Increases Phosphorylation of Akt and its Downstream Signaling Targets and Suppresses Apoptosis after Traumatic Brain Injury

OBJECT: Our previous studies found that simvastatin treatment of traumatic brain injury (TBI) in rats had beneficial effects on spatial learning functions. In the current study we wanted to determine whether simvastatin suppressed neuronal cell apoptosis after TBI, and if so, the underlying mechanis...

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Detalhes bibliográficos
Main Authors: Wu, Hongtao, Lu, Dunyue, Jiang, Hao, Xiong, sYe, Qu, Changsheng, Li, Bo, Mahmood, Asim, Zhou, Dong, Chopp, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703644/
https://ncbi.nlm.nih.gov/pubmed/18826357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/JNS/2008/109/10/0691
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