Caspase-independent cell death is involved in the negative effect of EGFR inhibitors on cisplatin in non-small cell lung cancer cells

PURPOSE: Results of multiple clinical trials suggest that EGFR tyrosine kinase inhibitors (TKIs) exhibit negative effects on platinum-based chemotherapy in lung cancer patients with wild type (wt) EGFR, but the underlying molecular mechanisms are still uncertain. Studies that identify the mechanism...

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Huvudupphovsmän: Yamaguchi, Hirohito, Hsu, Jennifer L., Chen, Chun-Te, Wang, Ying-Nai, Hsu, Ming-Chuan, Chang, Shih-Shin, Du, Yi, Ko, How-Wen, Herbst, Roy, Hung, Mien-Chie
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703145/
https://ncbi.nlm.nih.gov/pubmed/23344263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2621
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