Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway

Pyruvate kinase is a key enzyme in the glycolytic pathway that converts phosphoenolpyruvate to pyruvate, and the M2 isoform of pyruvate kinase (PKM2) is associated with cancer. PKM2 has been reported to function independently of its pyruvate kinase activity, which is crucial for cancer cell prolifer...

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Publicat a:Am J Cancer Res
Autors principals: Hsu, Ming-Chuan, Hung, Wen-Chun, Yamaguchi, Hirohito, Lim, Seung-Oe, Liao, Hsin-Wei, Tsai, Chia-Hua, Hung, Mien-Chie
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851842/
https://ncbi.nlm.nih.gov/pubmed/27152240
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