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Homeostatic control of Argonaute stability by microRNA availability

Homeostatic mechanisms regulate the abundance of many small RNA components. We used Drosophila and mammalian systems to demonstrate a conserved homeostatic system in which the status of miRNA biogenesis controls Argonaute protein stability. Clonal analyses of multiple mutants of core Drosophila miRN...

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Autori principali: Smibert, Peter, Yang, Jr-Shiuan, Azzam, Ghows, Liu, Ji-Long, Lai, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702675/
https://ncbi.nlm.nih.gov/pubmed/23708604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2606
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