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C560Rβ3 caused platelet integrin αIIbβ3 to Bind Fibrinogen Continuously yet Resulted in a Severe Bleeding Syndrome and Increased Murine Mortality
BACKGROUND AND OBJECTIVES: β3-deficient(−/−) megakaryocytes were modified by human β3-lentivirus transduction and transplantation to express sufficient levels of a C560Rβ3 amino acid substitution to investigate how an activated αIIbβ3 conformation affects platelets in vivo in mice. PATIENT/METHODS:...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3702628/ https://ncbi.nlm.nih.gov/pubmed/23551977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12209 |
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