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Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding
This study demonstrates that two orthogonal events regulate integrin αIIbβ3’s interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the αIIb–β3 interface and (2) flexibility in the carboxy terminus of fibrinogen’s γ-module. The first postulate was tested by ca...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210020/ https://ncbi.nlm.nih.gov/pubmed/20828133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1009858 |
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