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Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase
The ‘radical S-adenosyl-L-methionine (AdoMet)’ enzyme Cfr methylates adenosine 2503 of the 23S rRNA in the peptidyltransferase centre (P-site) of the bacterial ribosome. This modification protects host bacteria, notably methicillin-resistant Staphylococcus aureus (MRSA), from numerous antibiotics, i...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3702613/ https://ncbi.nlm.nih.gov/pubmed/23861844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067979 |
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