Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase.

The 'radical S-adenosyl-L-methionine (AdoMet)' enzyme Cfr methylates adenosine 2503 of the 23S rRNA in the peptidyltransferase centre (P-site) of the bacterial ribosome. This modification protects host bacteria, notably methicillin-resistant Staphylococcus aureus (MRSA), from numerous anti...

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Main Authors: Martin R Challand, Enrico Salvadori, Rebecca C Driesener, Christopher W M Kay, Peter L Roach, James Spencer
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2013-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3702613?pdf=render
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