Survival motor neuron protein reduction deregulates autophagy in spinal cord motoneurons in vitro

Spinal muscular atrophy (SMA) is a genetic disorder characterized by degeneration of spinal cord motoneurons (MNs), resulting in muscular atrophy and weakness. SMA is caused by mutations in the Survival Motor Neuron 1 (SMN1) gene and decreased SMN protein. SMN is ubiquitously expressed and has a gen...

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Autores principales: Garcera, A, Bahi, N, Periyakaruppiah, A, Arumugam, S, Soler, R M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702296/
https://ncbi.nlm.nih.gov/pubmed/23788043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.209
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