Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models

Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 (SMN1) gene. SMA is characterized by the degeneration of spinal cord motoneurons (MNs), progressive skeletal muscle atrophy, and weakness. The cellular and molecular mechanisms causing MN l...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: de la Fuente, Sandra, Sansa, Alba, Hidalgo, Iván, Vivancos, Nuria, Romero-Guevara, Ricardo, Garcera, Ana, Soler, Rosa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316821/
https://ncbi.nlm.nih.gov/pubmed/32587237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2688-5
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