Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons

Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and deficient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. Nevertheless, the mechanism by which SMN reduction in muscle contributes...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Sansa, Alba, Hidalgo, Ivan, Miralles, Maria P., de la Fuente, Sandra, Perez-Garcia, M. Jose, Munell, Francina, Soler, Rosa M., Garcera, Ana
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254901/
https://ncbi.nlm.nih.gov/pubmed/34217376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-021-01223-5
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