Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3

Past studies have shown that histone deacetylase (HDAC) and mutant BRAF (v-Raf murine sarcoma viral oncogene homolog B1) inhibitors synergistically kill melanoma cells with activating mutations in BRAF. However, the mechanism(s) involved remains less understood. Here, we report that combinations of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lai, F, Guo, S T, Jin, L, Jiang, C C, Wang, C Y, Croft, A, Chi, M N, Tseng, H-Y, Farrelly, M, Atmadibrata, B, Norman, J, Liu, T, Hersey, P, Zhang, X D
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702278/
https://ncbi.nlm.nih.gov/pubmed/23744355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.192
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