Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3

Past studies have shown that histone deacetylase (HDAC) and mutant BRAF (v-Raf murine sarcoma viral oncogene homolog B1) inhibitors synergistically kill melanoma cells with activating mutations in BRAF. However, the mechanism(s) involved remains less understood. Here, we report that combinations of...

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Autors principals: Lai, F, Guo, S T, Jin, L, Jiang, C C, Wang, C Y, Croft, A, Chi, M N, Tseng, H-Y, Farrelly, M, Atmadibrata, B, Norman, J, Liu, T, Hersey, P, Zhang, X D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702278/
https://ncbi.nlm.nih.gov/pubmed/23744355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.192
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