Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

UV-induced DNA damage causes repression of RNA synthesis. Following the removal of DNA lesions, transcription recovery operates through a process that is not understood yet. Here we show that knocking-out of the histone methyltransferase DOT1L in mouse embryonic fibroblasts (MEF(DOT1L)) leads to a U...

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Detalhes bibliográficos
Main Authors: Oksenych, Valentyn, Zhovmer, Alexander, Ziani, Salim, Mari, Pierre-Olivier, Eberova, Jitka, Nardo, Tiziana, Stefanini, Miria, Giglia-Mari, Giuseppina, Egly, Jean-Marc, Coin, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701700/
https://ncbi.nlm.nih.gov/pubmed/23861670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003611
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