Impaired α(IIb)β(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1

Platelet aggregation is essential for hemostasis, but can also cause myocardial infarction and stroke. A key but poorly understood step in platelet activation is increased function of the major adhesive receptor, α(IIb)β(3) integrin, which enables adhesion and aggregation. Phospholipases (PL), in re...

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Main Authors: Elvers, Margitta, Stegner, David, Hagedorn, Ina, Kleinschnitz, Christoph, Braun, Attila, Kuijpers, Marijke E.J., Boesl, Michael, Chen, Qin, Heemskerk, Johan W. M., Stoll, Guido, Frohman, Michael A., Nieswandt, Bernhard
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701458/
https://ncbi.nlm.nih.gov/pubmed/20051593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000551
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