The structural basis of R-spondin recognition by LGR5 and RNF43

R-spondins (RSPOs) enhance Wnt signaling, affect stem cell behavior, bind to leucine-rich repeat-containing G-protein-coupled receptors 4–6, (LGR4–6) and the transmembrane E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3). The structure of RSPO1 bound to both LGR5 and RNF43 ec...

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Autori principali: Chen, Po-Han, Chen, Xiaoyan, Lin, Zhenghong, Fang, Deyu, He, Xiaolin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2013
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701190/
https://ncbi.nlm.nih.gov/pubmed/23756651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.219915.113
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