Amplification of a cloned Chinese hamster dihydrofolate reductase gene after transfer into a dihydrofolate reductase-deficient cell line.

We have transformed a dihydrofolate reductase (DHFR)-deficient Chinese hamster ovary cell line to the DHFR+ phenotype with a recombinant cosmid (cH1) containing a functional Chinese hamster DHFR gene (J.D. Milbrandt et al., Mol. Cell. Biol. 3:1266-1273, 1983). After exposure of cells to successive i...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Milbrandt, J D, Azizkhan, J C, Hamlin, J L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6310371/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.3.7.1274-1282.1983
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