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Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry

A library of neutral, hydrophobic reagents was synthesized for use as derivatizing agents in order to increase the ion abundance of N-linked glycans in electrospray ionization mass spectrometry (ESI MS). The glycans are derivatized via hydrazone formation and are shown to increase the ion abundance...

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Main Authors: Walker, S. Hunter, Lilley, Laura M., Enamorado, Monica F., Comins, Daniel L., Muddiman, David C.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700344/
https://ncbi.nlm.nih.gov/pubmed/21953184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-011-0140-x
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