Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a

Interleukin-1β (IL-1β) is a potent proinflammatory and immunoregulatory cytokine playing an important role in the progression of rheumatoid arthritis (RA). However, the signaling network of IL-1β in synoviocytes from RA patients is still poorly understood. Here, we show for the first time that phosp...

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Main Authors: Kang, Dong Woo, Park, Mi-Kyung, Oh, Hye-Joa, Lee, Dong-Gun, Park, Sung-Hwan, Choi, Kang-Yell, Cho, Mi-La, Min, Do Sik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700130/
https://ncbi.nlm.nih.gov/pubmed/23689131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01519-12
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