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The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5

Endocytosis is differentially regulated by hypoxia-inducible factor-1α (HIF-1α) and phospholipase D (PLD). However, the relationship between HIF-1α and PLD in endocytosis is unknown. HIF-1α is degraded through the prolyl hydroxylase (PHD)/von Hippel–Lindau (VHL) ubiquitination pathway in an oxygen-d...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Park, Mi Hee, Choi, Kang-Yell, Min, Do Sik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686693/
https://ncbi.nlm.nih.gov/pubmed/26680696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2015.101
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