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Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity
Hypoxia-inducible factor-1α (HIF-1α) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1α protein is determined by oxygen-dependent prolyl hydroxylation, which is required for bi...
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| 發表在: | Exp Mol Med |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4673472/ https://ncbi.nlm.nih.gov/pubmed/26611735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2015.87 |
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