Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity

Hypoxia-inducible factor-1α (HIF-1α) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1α protein is determined by oxygen-dependent prolyl hydroxylation, which is required for bi...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Exp Mol Med
Asıl Yazarlar: Park, Mi Hee, Bae, Sun Sik, Choi, Kang-Yell, Min, Do Sik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673472/
https://ncbi.nlm.nih.gov/pubmed/26611735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2015.87
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