Potent Antitrypanosomal Activities of Heat Shock Protein 90 Inhibitors In Vitro and In Vivo

African sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is universally fatal if untreated, and current drugs are limited by severe toxicities and difficult administration. New antitrypanosomals are greatly needed. Heat shock protein 90 (Hsp90) is a conserved and ubiquitously...

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Bibliographic Details
Main Authors: Meyer, Kirsten J., Shapiro, Theresa A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699005/
https://ncbi.nlm.nih.gov/pubmed/23630365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit179
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