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Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins

Expression of the mammalian pyruvate kinase M (PKM) gene provides an important example of mutually exclusive splicing. We showed previously that the hnRNP proteins A1, A2 and PTB play a critical role in this process. Here we provide evidence that concentration-dependent interactions involving a netw...

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Detalhes bibliográficos
Main Authors: Chen, Mo, David, Charles J., Manley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698866/
https://ncbi.nlm.nih.gov/pubmed/22307054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2219
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