Consequences of the combined loss of BOK and BAK or BOK and BAX

The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of apoptogenic factors such as cytochrome-c, which promote activation of the caspase cascade a...

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Bibliografiske detaljer
Main Authors: Ke, F, Bouillet, P, Kaufmann, T, Strasser, A, Kerr, J, Voss, A K
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698543/
https://ncbi.nlm.nih.gov/pubmed/23744350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.176
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