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Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

The proapoptotic members of the Bcl-2 family can be subdivided into members that contain several Bcl-2 homology (BH) domains and those that contain only the BH3 domain. Although it is known that BH3-only proteins and the multi-BH domain proteins, Bak and Bax, are essential for programmed cell death,...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Hutcheson, Jack, Scatizzi, John C., Bickel, Emily, Brown, Nathaniel J., Bouillet, Philippe, Strasser, Andreas, Perlman, Harris
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Rockefeller University Press 2005
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212027/
https://ncbi.nlm.nih.gov/pubmed/15967824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041484
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