Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK

It is well established that BAX and BAK play crucial, overlapping roles in the intrinsic pathway of apoptosis. Gene targeted mice lacking both BAX and BAK have previously been generated, but the majority of these animals died perinatally. BOK is a poorly studied relative of BAX and BAK that shares e...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Ke, F, Grabow, S, Kelly, G L, Lin, A, O'Reilly, L A, Strasser, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632322/
https://ncbi.nlm.nih.gov/pubmed/26492371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.304
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