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Raiding the pharmacy: genomic screening identifies known chemotherapies as negative regulators of MCL1

Despite multiple studies demonstrating the importance of the anti-apoptotic protein Mcl-1 in tumor cell survival and treatment resistance, a clinically important inhibitor has yet to be developed. A recent study by Guo Wei and colleagues published in Cancer Cell has utilized a novel high-throughput...

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Hlavní autoři: Pfannenstiel, Lukas W, Demelash, Abeba, Gastman, Brian R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698534/
https://ncbi.nlm.nih.gov/pubmed/22742055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm352
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