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Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain
Unlike other antiapoptotic Bcl-2 family members, Mcl-1 also mediates resistance to cancer therapy by uniquely inhibiting chemotherapy-induced senescence (CIS). In general, Bcl-2 family members regulate apoptosis at the level of the mitochondria through a common prosurvival binding groove. Through mu...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571950/ https://ncbi.nlm.nih.gov/pubmed/26205817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663898 |
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