T cell–derived inducible nitric oxide synthase switches off T(H)17 cell differentiation

RORγt is necessary for the generation of T(H)17 cells but the molecular mechanisms for the regulation of T(H)17 cells are still not fully understood. We show that activation of CD4(+) T cells results in the expression of inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced...

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Main Authors: Yang, Jianjun, Zhang, Ruihua, Lu, Geming, Shen, Yu, Peng, Liang, Zhu, Chen, Cui, Miao, Wang, Weidong, Arnaboldi, Paul, Tang, Meng, Gupta, Monica, Qi, Chen-Feng, Jayaraman, Padmini, Zhu, Hongfa, Jiang, Bo, Chen, Shu-hsia, He, John Cijiang, Ting, Adrian T., Zhou, Ming-Ming, Kuchroo, Vijay K., Morse, Herbert C., Ozato, Keiko, Sikora, Andrew G., Xiong, Huabao
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698516/
https://ncbi.nlm.nih.gov/pubmed/23797094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122494
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