T cell–derived inducible nitric oxide synthase switches off T(H)17 cell differentiation

RORγt is necessary for the generation of T(H)17 cells but the molecular mechanisms for the regulation of T(H)17 cells are still not fully understood. We show that activation of CD4(+) T cells results in the expression of inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced...

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Detalhes bibliográficos
Main Authors: Yang, Jianjun, Zhang, Ruihua, Lu, Geming, Shen, Yu, Peng, Liang, Zhu, Chen, Cui, Miao, Wang, Weidong, Arnaboldi, Paul, Tang, Meng, Gupta, Monica, Qi, Chen-Feng, Jayaraman, Padmini, Zhu, Hongfa, Jiang, Bo, Chen, Shu-hsia, He, John Cijiang, Ting, Adrian T., Zhou, Ming-Ming, Kuchroo, Vijay K., Morse, Herbert C., Ozato, Keiko, Sikora, Andrew G., Xiong, Huabao
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698516/
https://ncbi.nlm.nih.gov/pubmed/23797094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122494
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