Recombinant Human Adenovirus-p53 Injection Induced Apoptosis in Hepatocellular Carcinoma Cell Lines Mediated by p53-Fbxw7 Pathway, Which Controls c-Myc and Cyclin E

F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination-mediated suppression of several oncoproteins including c-Myc, cyclin E, Notch, c-Jun and others. Our previous study has indicated that low expression of Fbxw7 was negativel...

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Bibliografische gegevens
Hoofdauteurs: Tu, Kangsheng, Zheng, Xin, Zhou, Zhenyu, Li, Chao, Zhang, Jing, Gao, Jie, Yao, Yingmin, Liu, Qingguang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698167/
https://ncbi.nlm.nih.gov/pubmed/23840897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068574
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