Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma

BACKGROUND: The E3 ubiquitin ligase Fbxw7 functions as a general tumor suppressor by targeting several well-known oncoproteins for ubiquitination and proteasomal degradation. However, the clinical significance of Fbxw7 and the mechanisms involved in the anti-cancer effect of Fbxw7 in HCC are not cle...

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Bibliographische Detailangaben
Hauptverfasser: Tu, Kangsheng, Yang, Wei, Li, Chao, Zheng, Xin, Lu, Zhongtang, Guo, Cheng, Yao, Yingmin, Liu, Qingguang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035898/
https://ncbi.nlm.nih.gov/pubmed/24884509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-110
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