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Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of HO-1 expression in macrophages (Mϕ) is strict...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3697604/ https://ncbi.nlm.nih.gov/pubmed/23630967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00251-13 |
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