Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

Infection by Plasmodium, the causative agent of malaria, is associated with hemolysis and therefore with release of hemoglobin from RBC. Under inflammatory conditions, cell-free hemoglobin can be oxidized, releasing its heme prosthetic groups and producing deleterious free heme. Here we demonstrate...

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Detalhes bibliográficos
Main Authors: Seixas, Elsa, Gozzelino, Raffaella, Chora, Ângelo, Ferreira, Ana, Silva, Gabriela, Larsen, Rasmus, Rebelo, Sofia, Penido, Carmen, Smith, Neal R., Coutinho, Antonio, Soares, Miguel P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728109/
https://ncbi.nlm.nih.gov/pubmed/19706490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903419106
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