Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation

Heme oxygenase–1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin. We report that expression of HO-1 dictates the pathologic outcome of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). Induction of EAE...

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Hauptverfasser: Chora, Ângelo A., Fontoura, Paulo, Cunha, Andreia, Pais, Teresa F., Cardoso, Sílvia, Ho, Peggy P., Lee, Lowen Y., Sobel, Raymond A., Steinman, Lawrence, Soares, Miguel P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770945/
https://ncbi.nlm.nih.gov/pubmed/17256058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28844
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