Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by generating the gaseous molecule carbon monoxide (CO). Overexpression of HO-1, or induction of HO-1 expression by heme, prot...

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Bibliographic Details
Main Authors: Brouard, Sophie, Otterbein, Leo E., Anrather, Josef, Tobiasch, Edda, Bach, Fritz H., Choi, Augustine M.K., Soares, Miguel P.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193315/
https://ncbi.nlm.nih.gov/pubmed/11015442
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