Toll-Like Receptor 9 Is Required for Full Host Resistance to Mycobacterium avium Infection but Plays No Role in Induction of Th1 Responses

To investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium, TLR9, TLR2, and MyD88 knockout (KO) mice were infected with this bacterium. Bacterial burdens were higher in the spleens, livers, and lungs of infected TLR9 KO mice than in those of C57BL/6 mice, indica...

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Detalhes bibliográficos
Main Authors: Carvalho, Natália B., Oliveira, Fernanda S., Durães, Fernanda V., de Almeida, Leonardo A., Flórido, Manuela, Prata, Luana O., Caliari, Marcelo V., Appelberg, Rui, Oliveira, Sérgio C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067546/
https://ncbi.nlm.nih.gov/pubmed/21300776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01030-10
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